• Alonso A, Hennerici MG, Meairs S (eds.). Translational Neurosonology. Front Neurol Neurosci. 2015;36.
• Alonso A, Artemis D, Hennerici MG. Molecular Imaging of Carotid Plaque Vulnerability.Cerebrovasc Dis. 2014 Dec 24;39(1):5-12.
• Bolognese M, Artemis D, Alonso A, Hennerici MG, Meairs S, Kern R. Real-time ultrasound perfusion imaging in acute stroke: assessment of cerebral perfusion deficits related to arterial recanalization. Ultrasound Med Biol. 2013 May;39(5):745-52.
• Alonso A, Reinz E, Leuchs B, Kleinschmidt J, Fatar M, Geers B, Lentacker I, Hennerici MG, de Smedt SC, Meairs S. Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening. Mol Ther Nucleic Acids. 2013 Feb 19;2:e73.
• Meairs S, Alonso A, Hennerici MG. Progress in sonothrombolysis for the treatment of stroke. Stroke. 2012 Jun;43(6):1706-10.
• Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Hernandez Hernandez R, Jaff M, Kownator S, Naqvi T, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis. 2012;34(4):290-6.
• Kern R, Diels A, Pettenpohl J, Kablau M, Brade J, Hennerici MG, Meairs S. Real-time ultrasound brain perfusion imaging with analysis of microbubble replenishment in acute MCA stroke. J Cereb Blood Flow Metab 2011;31(8):1716-24.
• Alonso A, Dempfle CE, Della MA, Stroick M, Fatar M, Zohsel K, Allemann E, Hennerici MG, Meairs S. In vivo clot lysis of human thrombus with intravenous abciximab immunobubbles and ultrasound. Thromb Res 2009; 124: 70-4.
• Fatar M, Stroick M, Griebe M, Alonso A, Kreisel S, Kern R, Hennerici M, Meairs S. Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia. Ultrasound Med Biol 2008; 34: 1414-20.
• Kern R, Kablau M, Sallustio F, Fatar M, Stroick M, Hennerici MG, Meairs S. Improved detection of intracerebral hemorrhage with transcranial ultrasound perfusion imaging. Cerebrovasc Dis. 2008;26(3):277-83.
• Alonso A, Della Martina A., Stroick M, Fatar M, Griebe M, Pochon S, Schneider M, Hennerici M, Allemann E, Meairs S. Molecular imaging of human thrombus with novel abciximab immunobubbles and ultrasound. Stroke 2007; 38: 1508-14.
• Stroick M, Alonso A, Fatar M, Griebe M, Kreisel S, Kern R, Gaud E, Arditi M, Hennerici M, Meairs S. Effects of simultaneous application of ultrasound and microbubbles on intracerebral hemorrhage in an animal model. Ultrasound Med Biol 2006; 32: 1377-82.
• Kern R, Perren F, Kreisel S, Szabo K, Hennerici M, Meairs S. Multi-planar transcranial ultrasound imaging - standards, landmarks and correlation with magnetic resonance imaging. Ultrasound Med Biol 2005; 31: 311-5.
• Kern R, Perren F, Schoeneberger K, Gass A, Hennerici M, Meairs S. Ultrasound microbubble destruction imaging in acute middle cerebral artery stroke. Stroke 2004; 35: 1665-70.
• Daffertshofer M, Hennerici M. Ultrasound in the treatment of ischaemic stroke. Lancet Neurol 2003; 2: 283-90.
• Meairs S, Daffertshofer M, Neff W, Eschenfelder C, Hennerici M. Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion. Lancet 2000; 355: 550-1.

Neue Strategie in der Schlaganfallbehandlung?

Neue Stu­dien haben gezeigt, dass interventionelle Thromb­ektomieverfahren in Ergänzung zur iv Thrombolyse innerhalb eines kurzen Zeitfensters von maximal 6 Stunden und bei strenger Auswahl der indi­vi­du­ellen Schlaganfall­situation das Behandlungs­ergebnis ver­bes­sern können - anders als dies bis 2014 in vielen Vor­un­ter­suchungen belegt werden konnte. Die aktuellen Da­ten stehen aber noch im Kreuz­feuer der Kritik und wurden auf der ESC in Wien intensiv und kontrovers diskutiert - auch unsere internationale Zeit­schrift Cerebrovascular Diseases ruft ihre Leserschaft aktuell zur Diskussion auf. Letters oder Comments können auf der Webseite von Cerebrovascular Diseases mit der Bemerkung ‘ESC Discussion Forum’ zur Ver­öffentlichung eingereicht wer­den.

Wolf ME, Capelle HH, Lütjens G, Ebert A, Hennerici MG, Krauss JK, Blahak C. Body weight gain in patients with bilateral deep brain stimu­lation for dystonia. J Neural Transm 2015, epub

We aimed to analyse the changes of body weight following deep brain stimu­lation (DBS) in patients with dystonia. The body mass index (BMI) of 17 consecutive patients with segmental or generalised dystonia with bilateral DBS of the globus pallidus internus (GPi) or the thalamic ventral intermediate nucleus (VIM) was measured preoperatively (pre-OP) and at three follow-up (FU) time points post-DBS surgery. All patients benefited from marked improvement in their dystonia illustrated by the BFM motor score. The mean BMI pre-OP significantly increased post-operatively in particular during the first 6 months post-OP (see figure). This probably is a result of improvement of dystonic motor symptoms and recovery of eating dysfunction rather than a target-specific phenomenon. Patients should be informed pre-OP about this aspect.

Chatzikonstantinou A, Ebert AD, Hennerici MG. Temporal seizure focus and status epi­lepticus are associated with high-sensitive tro­po­nin I ele­va­tion after epi­leptic seizures. Epilepsy Res. 2015;115:77-80

The purpose of this study was to evaluate the association of postictal ele­vation of troponin I (TNI) with seizure type and focus, as well as vascular risk factors. Postictal TNI elevation was found in about 11% of patients and was significantly more common in older patients with status epilepticus or temporal seizure focus. These data support the concept of relevant cardiac effects of seizures, especially of those with temporal lobe focus.

Okazaki S, Hornberger E, Griebe M, Gass A, Hennerici MG, Szabo K. MRI Charac­teristics of the Evolution of Supratentorial Recent Small Subcortical Infarcts. Front Neurol. 2015

The purpose of the present study was to describe the MRI characteristics of the evolution of recent small subcortical infarcts. We showed that more than one-third of recent small subcortical infarcts do not lead to cavity formation and 40% of infarct lesions overlap with white matter hyperintensities (WMHs). These data indicate the continuity between recent small subcortical infarcts and WMHs.

The Lancet Neurology, Volume 12, Issue 6, Pages 572 - 584, June 2013

Non-pharmacological strategies for the treatment of acute ischaemic stroke

Prof Michael G Hennerici MD, Rolf Kern MD, Prof Kristina Szabo MD

Summary

Early recanalisation and an increase in collateral blood supply are predictors of favourable outcome in acute ischaemic stroke. Since individual responses to intravenous treatment with alteplase are heterogeneous, additional intra-arterial thrombolytic and mechanical endovascular treatment is increasingly given. Despite encouraging findings from single-centre studies, data from randomised clinical trials have not proven the hypothesis that interventional recanalisation leads to a better outcome. Advanced thrombectomy devices, the effect of ultrasound-enhanced thrombolysis, and imaging-guided selection of patients outside the currently approved time-window are all under investigation. Although neuroprotective agents have not shown benefit in clinical trials, non-pharmacological treatment strategies—such as decompressive surgery, therapeutic hypothermia, transcranial laser treatment, or augmentation of cerebral collateral perfusion by different means (eg, partial aortic occlusion or sphenopalatine ganglion stimulation)—are topics of current research. The future of acute stroke therapy relies on evidence for individually tailored, effective, safe, and rapidly accessible treatment probably consisting of combined pharmacological and improved non-pharmacological approaches. Fulltext